The objective of this project is to examine the nature of the interactions between radiation and chemicals at low doses and dose rates with particular emphasis on the potential tumor enhancing or cocarcinogenic activity of low dose rate radiation exposures. Specifically this research wiLl examine: 1) whether the carcinogenic effectiveness of the radiation dose influences of a chemical carcinogen and low dose rate radiation; 3) the influence of radiation quality on these interactions. In these studies the effects of varying doses and dose rates of 137Cs gamma ray of fission neutron irradiation on the development of mammary adenocarcinomas in BALB/c mice after an initial exposure to low doses of 1.12-dimethylbenz(a)anthracene will be determined.